Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4012 | 4012-30414 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I | K219Q | K103N, Y181YC, G190A | K20R, V35I, T39TS, K64H, T69N, K122E, D123DN, I178IL, T200A, E203K, Q207E, H208Y, L228H, A272P, I293V, E297K, I329V, G333E, Q334P, R356K, A360T, K366KR, I375IV, T386I, E399D |
| >4012-30414| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICSEMEKEGKISKIGPENPYNTPV FAIHKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI CQYMDDLYVASDLEIGQHRAKIKELREYLLRWGFTTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQEPGQWTYQIYQEPFKNLKTGKYAKMRGT HTNDVRQLTEAVQKVATESIVIWGKIPKFKLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, E35D, M36T, N37D, R57K, I62V, L63P, A71V, I93L |
| >4012-30414| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEDTDLPGRWKPKMIGGIGGFIKVKQYD QVPIEICGHKVIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |