Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4011 | 4011-30331 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, K70R, M184I, L210W, T215Y | D67G, K219R | Y188L | F227L | K20R, K43Q, E44D, S68T, V106L, V118I, K122E, I135L, T165I, T200A, E203K, Q207E, H208Y, R211K, K223E, L228H, A272P, K277R, T286A, I293V, E297Q, D324E, R356K, M357T, G359C, A371V |
| >4011-30331| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKGTDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSLTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI YQYIDDLLVGSDLEIGQHRAKIKELREYLWKWGFYTPDRKHQEEPPLHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTQEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTRCA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V | L24I, Q58E | L10I, I15V, K20R, M36I, L63P, T74K, L89M, T91S |
| >4011-30331| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVREYD QIPIEICGHKAIGKVLVGPTPANVIGRNMLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |