Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4010 | 4010-30416 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67HN, K70R, L74IV, M184V, L210W, T215Y | K219Q | L100I, K103N, Y181I | K20R, V35I, K43KQ, T69N, I94IL, K122E, E138EQ, S162D, V179I, T200A, E203D, H208F, R211K, D218E, L228H, A272P, K277R, T286A, I293V, E297K, G333E, K350KR, R356K, M357I, A360T, A371V, I375V, A376V, T386A, K390R |
| >4010-30416| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV FAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGLPHPAGIKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNQTPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIII IQYVDDLYVGSDLEIGQHRAKIDELRQFLWKWGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLRTGKYAKIRGT HTNDVKQLTEVVQKVVTESIVIWGKAPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L10F, L33F, G73T | I62V, L63P, A71V, V77I, I93L, C95F |
| >4010-30416| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGFLKVRQYD QVPIEICGHKVITTVLIGPTPVNVIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |