<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4010 4010-30416 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54L, I84V, L90M L10F, L33F, G73T I62V, L63P, A71V, V77I, I93L, C95F  
>4010-30416| codons 1-99
PQITLWQRPFVTIKIGGQLKEALLDTGADDTIFEEMNLPGRWKPKIVGGIGGFLKVRQYD
QVPIEICGHKVITTVLIGPTPVNVIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67HN, K70R, L74IV, M184V, L210W, T215Y K219Q L100I, K103N, Y181I   K20R, V35I, K43KQ, T69N, I94IL, K122E, E138EQ, S162D, V179I, T200A, E203D, H208F, R211K, D218E, L228H, A272P, K277R, T286A, I293V, E297K, G333E, K350KR, R356K, M357I, A360T, A371V, I375V, A376V, T386A, K390R  
>4010-30416| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV
FAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGLPHPAGIKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNQTPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIII
IQYVDDLYVGSDLEIGQHRAKIDELRQFLWKWGFYTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLRTGKYAKIRGT
HTNDVKQLTEVVQKVVTESIVIWGKAPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006