<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4009 4009-40802 Germany 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 68

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184I, L210W, T215Y K219R Y181I   V21I, V35I, E44D, K101Q, V118I, K122E, D123N, I135T, I142V, S162A, T165L, V179I, I202V, E203K, H208Y, R211K, K223E, A272P, R356K, G359S, T386I, K390R Q91L
>4009-40802| codons 1-399
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVLLGIPHPAGLQKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQASMLKILEPFRKQNPDIII
IQYIDDLYVGSDLEIGQHRTKVKELRQYLWKWGFYTPDRKHQEEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, V82T L33F, K43T L10I, I13V, I15V, E34Q, E35D, M36L, R41RK, G51A, K55R, I62V, L63P, A71V, V77I, L89M  
>4009-40802| codons 1-99
PQITLWQRPIVTVKVGGQLKEALLDTGADDTVFQDLNLPGKWTPKIVGGIAGFVRVRQYD
QVPIEICGHKVIGTVLIGPTPTNIIGRNMLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006