Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4009 | 4009-30415 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | Y181I | V21I, V35VI, E44D, K101KQ, V118I, K122E, D123N, I135T, I142V, S162A, T165L, V179I, I202V, E203K, H208Y, R211K, K223E, A272P, Q343QH, R356K, G359GS, T386I, K390R | Q91L |
| >4009-30415| codons 1-399 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVLLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQASMLKILEPFRKQNPDIII IQYMDDLYVGSDLEIGQHRTKVKELRQYLWKWGFYTPDRKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYHEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, L76V, V82A | L33F, K43T | L10I, I13V, E34Q, M36L, R41RK, I62V, L63P, A71V |
| >4009-30415| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFQELNLPGKWTPKIVGGIGGFVKVRQYD QVPIEICGHKVIGTVVVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |