Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4007 | 4007-30327 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I50V, I54V, V82A, L90M | F53L | L10V, I15V, K20R, E34Q, E35D, M36V, N37E, I62V, L63P, A71L, V77L, I93L |
| >4007-30327| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTILQDVELPGRWKPKIVGGVGGLVKVRQYD QVPIEICGHKLIGTVLLGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, L210W, T215Y | K219D | K101E, Y181C, G190S | V35T, T39ALSV, E44D, V60I, K82KR, V118I, K122E, I135M, S162SN, H208HY, D218E, L228H, A272P, K277R, L283LI, I293V, E297A, I326V, R356K, G359S, T386I, K390R |
| >4007-30327| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICVELEKDGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNRRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI CQYMDDLYVSSDLEIGQHRTKIEELRQYLWRWGFYTPEDKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |