<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4005 4005-30314 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L210W, T215Y K219E K101E, Y181C, G190A A98G, V108I, V179FI P4T, T27TS, V35I, T39A, E44D, V106I, L109V, V118I, K122KE, D123E, D177E, E203K, H208Y, R211K, D218E, K223KQ, L228HR, V245K, A272S, V292VI, I293V, V317A, I329L, Q334P, G359S, V365I, A376S, T386I  
>4005-30314| codons 1-399
PISTIETVPVKLKPGMDGPKVKQWPLSEEKIKALIEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSITIVDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII
CQYMDDLYVASDLEIGQHRTKIKELRQYLWKWGFYTPEEKHQQEPPFRWMGYELHPDKWT
VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEIVPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAELQKQGPGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDIKQLTEAVQKISTESIVIWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L33F, K43T, F53L, G73S L10IV, G16GA, Q61E, I62V, L63P, A71V, I72K, T74S, V77VI  
>4005-30314| codons 1-99
PQITLWQRPVVTIKIAGQLKEALLDTGADDTVFEEMNLPGRWTPKIIGGIGGLVKVRQYD
EVPIEICGHKVKSSVLIGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006