Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4005 | 4005-30314 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L33F, K43T, F53L, G73S | L10IV, G16GA, Q61E, I62V, L63P, A71V, I72K, T74S, V77VI |
| >4005-30314| codons 1-99 PQITLWQRPVVTIKIAGQLKEALLDTGADDTVFEEMNLPGRWTPKIIGGIGGLVKVRQYD EVPIEICGHKVKSSVLIGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | K219E | K101E, Y181C, G190A | A98G, V108I, V179FI | P4T, T27TS, V35I, T39A, E44D, V106I, L109V, V118I, K122KE, D123E, D177E, E203K, H208Y, R211K, D218E, K223KQ, L228HR, V245K, A272S, V292VI, I293V, V317A, I329L, Q334P, G359S, V365I, A376S, T386I |
| >4005-30314| codons 1-399 PISTIETVPVKLKPGMDGPKVKQWPLSEEKIKALIEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSITIVDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII CQYMDDLYVASDLEIGQHRTKIKELRQYLWKWGFYTPEEKHQQEPPFRWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEIVPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAELQKQGPGQWTYQIYQEPFKNLKTGKYARMRSA HTNDIKQLTEAVQKISTESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |