<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4004 4004-30312 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54A, V82A, L90M L33F, Q58E L10V, L19I, E34Q, D60E, L63P, A71V, I72IV, I93L  
>4004-30312| codons 1-99
PQITLWQRPVVTIKIGGQIKEALLDTGADDTVFQEMNLPGRWKPKLIGGIGGFAKVREYE
QIPIEICGHKVVGTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, T215Y V75M, K219E, N348I Y181I V108I, V179D, F227L T39TA, E44AD, K122E, D123E, I135T, S162C, D177E, I178L, E203K, Q207E, K223E, L228H, Q242K, A272P, K277R, G333E, Q334L, P345Q, G359S, A371AV, T386I, K390R  
>4004-30312| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTRWRKIMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPELDI
IQYVDDLYVGSDLEIGQHRTKIKELREHLLRWGFYTPDEKHQEEPPLHWMGYELHPDKWT
VKPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQELGQWTYQIYQEQFKILKTGKYARMRSA
HTNDVKQLTEVVQKIATESIVIWGKIPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006