Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4004 | 4004-30312 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54A, V82A, L90M | L33F, Q58E | L10V, L19I, E34Q, D60E, L63P, A71V, I72IV, I93L |
| >4004-30312| codons 1-99 PQITLWQRPVVTIKIGGQIKEALLDTGADDTVFQEMNLPGRWKPKLIGGIGGFAKVREYE QIPIEICGHKVVGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75M, M184V, T215Y | K219E, N348I | Y181I | V108I, V179D, F227L | T39TA, E44AD, K122E, D123E, I135T, S162C, D177E, I178L, E203K, Q207E, K223E, L228H, Q242K, A272P, K277R, G333E, Q334L, P345Q, G359S, A371AV, T386I, K390R |
| >4004-30312| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKIMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPELDI IQYVDDLYVGSDLEIGQHRTKIKELREHLLRWGFYTPDEKHQEEPPLHWMGYELHPDKWT VKPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQELGQWTYQIYQEQFKILKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKIPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |