<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4001 4001-30311 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, L90M L10F, F53FL T4A, T12K, I13V, K14KR, K20T, M36I, R41K, D60E, I62V, L63P, A71T, I93L, C95F  
>4001-30311| codons 1-99
PQIALWQRPFVKVRIGGQLTEALLDTGADDTVLEEINLPGKWKPKIVGGIGGLVKVRQYE
QVPIEICGHKTIGTVLVGPTPVNIIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Q151M, M184V A62V, V75VI, F77FL, F116Y K103N, Y181YC V108VI T39TA, S68G, K122E, I135T, S162D, K166R, G196E, T200TA, F214L, V245E, V276I, L283I, I293V, E297EAKT, P345Q, K366R, K385KR, T386I, K390R  
>4001-30311| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV
FVIKRKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYYSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQDSMTRILEPFRKQNPDIVI
CQYVDDLYVGSDLEIEQHRAKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKIKQLCKLIRGTKALTEVVPLTTEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEQFKNLKTGKYARMRGA
HTNDVRQLTEAVQKIATESIVIWGRIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006