Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4001 | 4001-30311 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, L90M | L10F, F53FL | T4A, T12K, I13V, K14KR, K20T, M36I, R41K, D60E, I62V, L63P, A71T, I93L, C95F |
| >4001-30311| codons 1-99 PQIALWQRPFVKVRIGGQLTEALLDTGADDTVLEEINLPGKWKPKIVGGIGGLVKVRQYE QVPIEICGHKTIGTVLVGPTPVNIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M, M184V | A62V, V75VI, F77FL, F116Y | K103N, Y181YC | V108VI | T39TA, S68G, K122E, I135T, S162D, K166R, G196E, T200TA, F214L, V245E, V276I, L283I, I293V, E297EAKT, P345Q, K366R, K385KR, T386I, K390R |
| >4001-30311| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAEMEKEGKISKIGPENPYNTPV FVIKRKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYYSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQDSMTRILEPFRKQNPDIVI CQYVDDLYVGSDLEIEQHRAKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKIKQLCKLIRGTKALTEVVPLTTEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEQFKNLKTGKYARMRGA HTNDVRQLTEAVQKIATESIVIWGRIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |