<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3373 3373-30620 Belgium 2003 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48V, I54V, V82A   L10V, I15V, L19I, R41K, I62V, L63S, I64L, V77I  
>3373-30620| codons 1-99
PQITLWQRPVVTIKVGGQIKEALLDTGADDTVLEEMNLPGKWKPKLIVGIGGFVKVRQYD
QVSLEICGHKAIGTVLIGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, L74V, M184V K219Q     P4T, T7TP, V35T, K49R, V60I, V106VI, D121C, K122E, I142V, T165I, E169D, D177E, I178L, I202V, Q207E, R211K, F214L, V245Q, D250E, A272P, K277R, T286A, V292VI, E297K, G333E, Q334H, R356K, M357MIV, A360T, K390R Q197A
>3373-30620| codons 1-399
PISTIEPVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPI
FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL
CEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILDPFRKQNPELVI
YQYVDDLYVGSDLEIGAHRTKVEELREHLLKWGLTTPDQKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEIIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYAKVRGT
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006