Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3373 | 3373-30620 | Belgium | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A | L10V, I15V, L19I, R41K, I62V, L63S, I64L, V77I |
| >3373-30620| codons 1-99 PQITLWQRPVVTIKVGGQIKEALLDTGADDTVLEEMNLPGKWKPKLIVGIGGFVKVRQYD QVSLEICGHKAIGTVLIGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, L74V, M184V | K219Q | P4T, T7TP, V35T, K49R, V60I, V106VI, D121C, K122E, I142V, T165I, E169D, D177E, I178L, Q197A, I202V, Q207E, R211K, F214L, V245Q, D250E, A272P, K277R, T286A, V292VI, E297K, G333E, Q334H, R356K, M357MIV, A360T, K390R |
| >3373-30620| codons 1-399 PISTIEPVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPI FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL CEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILDPFRKQNPELVI YQYVDDLYVGSDLEIGAHRTKVEELREHLLKWGLTTPDQKHQKEPPFLWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEIIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYAKVRGT HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |