Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3344 | 3344-30602 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48A, I54V, V82T, I84V, L90M | K43T | T4S, L10I, I15V, L19I, K20R, E35D, M36I, N37T, R57K, I62IV, L63P, H69K, A71V, I85V, Q92R |
| >3344-30602| codons 1-98 PQISLWQRPIVTIKVGGQIREALLDTGADDTVLEDITLPGRWTPKLIAGIGGFVKVKQYD QVPIEICGKKVIGTVLVGPTPTNVVGRNLMTRIGCTLN |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74LV, M184V, L210W, T215Y | K219E | K101KE, Y181YC, G190GA | V108VI | E6D, V35I, V118I, Q174R, T200I, Q207E, R211K, L228H, E297K, I329L, M357T, S379C, T386TA, K390KR |
| >3344-30602| codons 1-399 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI CQYVDDLYVASDLEIGQHRIKIEELREHLWKWGFYTPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATECIVIWGKAPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |