<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3333 3333-30929 France 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74IV, V75T, M184V, L210W, T215Y A62V, D67DG K103N A98AG, V108VI K20R, V35T, T39D, E44D, S68G, V118I, K122E, I135L, I142IV, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, E224D, V245Q, D250E, S251D, A272P, L283LI, T286A, E291D, V292I, I293V, E312T, S322T, D324E, I326L, G335D, F346N, R356K, M357R, R358G, G359S, A371V, I375V, T377Q, Q394R, E399D I37IL
>3333-30929| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTELCDELEKDGKISKIGPENPYNTPV
FVIKKKGGTKWRKVTDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL
DEDFRKYTAFTIPSLNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEMVI
YQYVDDLYVGSDLEIGQHRAKIEELRAHLWSWGFYTPDKKHQKDPPFLWMGYELHPDKWT
VQPIQLPEKEDWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGAKALTDIVPLTEEAE
LELAENREILKTPVHGVYYDPTKELLAEIQKQGQDQWTYQIYQEPNKNLKTGKYAKRGSA
HTNDVKQLTEVVQKVAQESIVIWGKTPKFKLPIRKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, I84V L33F, G73S L10V, I13V, I15V, K20T, E35D, M36I, P39S, R41K, Q61D, I62V, L63P, I66F, H69K, T74S, L89T  
>3333-30929| codons 1-99
PQITLWQRPVVTVKVGGQLTEALLDTGADDTVFEDINLSGKWKPKIVGGIGGFVKVRQYD
DVPIEFCGKKAISSVLVGPTPVNVIGRNTLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006