Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3333 | 3333-30929 | France | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V | L33F, G73S | L10V, I13V, I15V, K20T, E35D, M36I, P39S, R41K, Q61D, I62V, L63P, I66F, H69K, T74S, L89T |
| >3333-30929| codons 1-99 PQITLWQRPVVTVKVGGQLTEALLDTGADDTVFEDINLSGKWKPKIVGGIGGFVKVRQYD DVPIEFCGKKAISSVLVGPTPVNVIGRNTLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74IV, V75T, M184V, L210W, T215Y | A62V, D67DG | K103N | A98AG, V108VI | K20R, V35T, T39D, E44D, S68G, V118I, K122E, I135L, I142IV, K173T, Q174K, D177E, I178M, T200A, Q207A, R211S, E224D, V245Q, D250E, S251D, A272P, L283LI, T286A, E291D, V292I, I293V, E312T, S322T, D324E, I326L, G335D, F346N, R356K, M357R, R358G, G359S, A371V, I375V, T377Q, Q394R, E399D | I37IL |
| >3333-30929| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTELCDELEKDGKISKIGPENPYNTPV FVIKKKGGTKWRKVTDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEMVI YQYVDDLYVGSDLEIGQHRAKIEELRAHLWSWGFYTPDKKHQKDPPFLWMGYELHPDKWT VQPIQLPEKEDWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGAKALTDIVPLTEEAE LELAENREILKTPVHGVYYDPTKELLAEIQKQGQDQWTYQIYQEPNKNLKTGKYAKRGSA HTNDVKQLTEVVQKVAQESIVIWGKTPKFKLPIRKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |