Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3331 | 3331-30925 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, T215F | K219Q | K103N, Y181C | T69N, K122E, E169ED, D177E, T200TA, D218E, V245K, I293V, E297A, E312EA, D324E, M357T, R358K, K390R |
| >3331-30925| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKAPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82S, L90M | L33F, G73S | T4P, L10I, R41K, K55R, I62V, L63P, C67F, A71V, I72L |
| >3331-30925| codons 1-99 PQIPLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGKWKPKIIGGIGGFVRVRQYD QVPIEIFGHKVLSTVLVGPTPSNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |