Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3328 | 3328-30924 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10F, V11VI, G73S | T4S, I13IV, I15V, K20I, E35D, M36I, R57RK, I62V, L63P, A71V, I72T |
| >3328-30924| codons 1-99 PQISLWQRPFITVKVGGQLIEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVKQYD QVPIEICGHKVTSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74LV, L210W, T215Y | V75VI, K219R | F227FL | K11RS, I31IL, V35VI, T39TA, K43KEQ, E44D, V60VI, V118I, K122E, I135T, G196E, E203K, Q207E, H208HY, R211K, K223KE, I293V, E297K, A371V, I375V, K390R |
| >3328-30924| codons 1-400 PISPIETVPVSLKPGMDGPKVKQWPLTEEKLKALIEICAELEQDGKISKIGPENPYNTPI FAIKKKNSDKWRKVIDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIKELREYLWKWGFYTPDRKHQEEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |