<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3328 3328-30924 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M L10F, V11VI, G73S T4S, I13IV, I15V, K20I, E35D, M36I, R57RK, I62V, L63P, A71V, I72T  
>3328-30924| codons 1-99
PQISLWQRPFITVKVGGQLIEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVKQYD
QVPIEICGHKVTSTVLVGPTPANIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74LV, L210W, T215Y V75VI, K219R   F227FL K11RS, I31IL, V35VI, T39TA, K43KEQ, E44D, V60VI, V118I, K122E, I135T, G196E, E203K, Q207E, H208HY, R211K, K223KE, I293V, E297K, A371V, I375V, K390R  
>3328-30924| codons 1-400
PISPIETVPVSLKPGMDGPKVKQWPLTEEKLKALIEICAELEQDGKISKIGPENPYNTPI
FAIKKKNSDKWRKVIDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIEQHRTKIKELREYLWKWGFYTPDRKHQEEPPLLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEVVQKVATESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006