Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3325 | 3325-30916 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A, I84IV, L90M | V11I, L33LF, Q58QE | L10V, I13V, I15V, K55KR, R57K, D60E, I62V, L63P, A71V, I72IM, V75VI, Q92QK |
| >3325-30916| codons 1-99 PQITLWQRPVITVKVGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFLRVKEYE QVPIEICGHKVMGTILVGPTPANVIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215Y | Y188YFHL, G190A | K11R, E44D, V60I, K101Q, K122E, D123Q, I135T, I142T, I178M, V179I, Q197K, T200A, I202V, Q207A, R211K, V245E, A272S, V292I, I293V, E297K, D324E, R356K, M357MT, G359GS, A371AV, I375V, K390R | V381VIM |
| >3325-30916| codons 1-400 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEQFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII YQYMDDLLVASDLEIGKHRAKVEELRAHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEIVPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTRSA HTNDVKQLTEVVQKVATESIMIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |