<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3325 3325-30916 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54L, V82A, I84IV, L90M V11I, L33LF, Q58QE L10V, I13V, I15V, K55KR, R57K, D60E, I62V, L63P, A71V, I72IM, V75VI, Q92QK  
>3325-30916| codons 1-99
PQITLWQRPVITVKVGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFLRVKEYE
QVPIEICGHKVMGTILVGPTPANVIGRNLMTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, L210W, T215Y   Y188YFHL, G190A   K11R, E44D, V60I, K101Q, K122E, D123Q, I135T, I142T, I178M, V179I, Q197K, T200A, I202V, Q207A, R211K, V245E, A272S, V292I, I293V, E297K, D324E, R356K, M357MT, G359GS, A371AV, I375V, K390R V381VIM
>3325-30916| codons 1-400
PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI
FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DEQFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMII
YQYMDDLLVASDLEIGKHRAKVEELRAHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEIVPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTRSA
HTNDVKQLTEVVQKVATESIMIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006