<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3320 3320-30917 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 3

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74I, L210W, T215Y   Y181C   V35M, E40F, K43Q, K49R, V90I, V118I, D123E, A158S, D177E, Q207E, R211K, L228H, E248D, K249Q, P294Q, E300Q, K311R, I329L, Q334D, R356K, T369A, A376S, K390R, K395R  
>3320-30917| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTFLEQEGKISRIGPENPYNTPV
FAIKKKNSDKWRKIVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPEIVI
CQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VQPIVLPDQDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIQLTEEAQ
LELAENREILREPVHGVYYDPSKDLIAELQKQGDGQWTYQIYQEPFKNLKTGKYAKMRGA
HTNDVKQLAEAVQKISTESIVIWGKTPKFRLPIQRETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82M, L90M L33I, Q58E L10V, K20R, E35D, M36I, N37D, K55R, R57K, Q61QE, I62V, L63P, K70T, A71V, L89M, I93L  
>3320-30917| codons 1-99
PQITLWQRPVVTIKIGGQLREALLDTGADDTVIEDIDLPGRWKPKIIGGIGGFVRVKEYD
EVPIEICGHTVIGTVVVGPTPMNIIGRNMMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006