Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3320 | 3320-30917 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 3 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, L210W, T215Y | Y181C | V35M, E40F, K43Q, K49R, V90I, V118I, D123E, A158S, D177E, Q207E, R211K, L228H, E248D, K249Q, P294Q, E300Q, K311R, I329L, Q334D, R356K, T369A, A376S, K390R, K395R |
| >3320-30917| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTFLEQEGKISRIGPENPYNTPV FAIKKKNSDKWRKIVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPDQDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIQLTEEAQ LELAENREILREPVHGVYYDPSKDLIAELQKQGDGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLAEAVQKISTESIVIWGKTPKFRLPIQRETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82M, L90M | L33I, Q58E | L10V, K20R, E35D, M36I, N37D, K55R, R57K, Q61QE, I62V, L63P, K70T, A71V, L89M, I93L |
| >3320-30917| codons 1-99 PQITLWQRPVVTIKIGGQLREALLDTGADDTVIEDIDLPGRWKPKIIGGIGGFVRVKEYD EVPIEICGHTVIGTVVVGPTPMNIIGRNMMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |