<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3318 3318-30924 France 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, M184V, L210W, T215Y K219N Y181C, G190A K101H P4T, I5IV, E6K, V21I, E28K, K32I, V35T, V60I, V111I, V118VI, K122E, I135V, K173A, Q174K, D177E, I178L, G196GE, T200A, E203EK, Q207E, H208Y, R211K, W212C, V245Q, E248D, D250E, A272P, E291D, V292I, I293V, S322A, D324E, I329V, Q334P, G335D, R356K, M357R, G359A, A371V, T377S, K390R V106T
>3318-30924| codons 1-399
PISTVKTVPVKLKPGMDGPKIKQWPLTKEKIIALTEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLHKKKSTTVLDIGDAYFSIPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPELVI
CQYVDDLYVASDLEIEQHRAKIKELREYLWKCGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPAKELIAEVQKQGPDQWTYQIYQEPFKNLKTGKYAKRRAA
HTNDVKQLTEVVQKIASESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82M, L90M K43T, T74P L10V, T12TK, I13V, K20I, E35D, M36IV, N37D, R41K, Q61QH, I62V, C67E, H69K, L89M  
>3318-30924| codons 1-99
PQITLWQRPVVKVKIGGQLIEALLDTGADDTVLEDVDLPGKWTPKMIVGIGGFVKVRQYD
HVLIEIEGKKAIGPVLVGPTPMNIIGRNMMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006