Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3318 | 3318-30924 | France | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219N | Y181C, G190A | K101H | P4T, I5IV, E6K, V21I, E28K, K32I, V35T, V60I, V111I, V118VI, K122E, I135V, K173A, Q174K, D177E, I178L, G196GE, T200A, E203EK, Q207E, H208Y, R211K, W212C, V245Q, E248D, D250E, A272P, E291D, V292I, I293V, S322A, D324E, I329V, Q334P, G335D, R356K, M357R, G359A, A371V, T377S, K390R | V106T |
| >3318-30924| codons 1-399 PISTVKTVPVKLKPGMDGPKIKQWPLTKEKIIALTEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLHKKKSTTVLDIGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPELVI CQYVDDLYVASDLEIEQHRAKIKELREYLWKCGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPAKELIAEVQKQGPDQWTYQIYQEPFKNLKTGKYAKRRAA HTNDVKQLTEVVQKIASESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82M, L90M | K43T, T74P | L10V, T12TK, I13V, K20I, E35D, M36IV, N37D, R41K, Q61QH, I62V, C67E, H69K, L89M |
| >3318-30924| codons 1-99 PQITLWQRPVVKVKIGGQLIEALLDTGADDTVLEDVDLPGKWTPKMIVGIGGFVKVRQYD HVLIEIEGKKAIGPVLVGPTPMNIIGRNMMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |