Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3316 | 3316-30818 | France | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, V82F | L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89M |
| >3316-30818| codons 1-99 PQITLWQRPIVKVKIAGQVIEALLDTGADDTVLENINLPGKWKPKMIGGIGGFAKVRQYE QIPIEICGKKAIGSVLIGPTPFNIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M | A62V, V75I, F77L, F116Y | K103H, Y181C, G190A | K101N | K11T, V35T, T39E, S68G, V118I, D121Y, K122E, D123S, A158S, R172K, K173S, Q174K, D177E, I195L, G196E, Q207A, R211S, F214L, H221Y, V245Q, T286A, E291D, I293V, E297K, E312D, H315Q, V317A, I326T, Q334D, R356K, M357K, G359S, T362S, K366R, T369V, E370D, A371V, I375V, A376S, K390R | P4K |
| >3316-30818| codons 1-399 PISKIETVPVTLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKISKIGPENPYNTPV FVIKRKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLNKHKSVTVLDVGDAYYSIPL YESFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPSIFQSSMTKILEPFKSKNPEIVI CQYMDDLYVASDLELEQHRTKIEELRAHLLSWGLTTPDKKYQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVPLTKEAE LELAENREILKDPVQGAYYDPSKDLTAEIQKQGDGQWTYQIYQEPFKNLKTGKYAKKRSA HSNDVRQLVDVVQKVSTESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |