<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3316 3316-30818 France 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54A, V82F   L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89M  
>3316-30818| codons 1-99
PQITLWQRPIVKVKIAGQVIEALLDTGADDTVLENINLPGKWKPKMIGGIGGFAKVRQYE
QIPIEICGKKAIGSVLIGPTPFNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Q151M A62V, V75I, F77L, F116Y K103H, Y181C, G190A K101N P4K, K11T, V35T, T39E, S68G, V118I, D121Y, K122E, D123S, A158S, R172K, K173S, Q174K, D177E, I195L, G196E, Q207A, R211S, F214L, H221Y, V245Q, T286A, E291D, I293V, E297K, E312D, H315Q, V317A, I326T, Q334D, R356K, M357K, G359S, T362S, K366R, T369V, E370D, A371V, I375V, A376S, K390R  
>3316-30818| codons 1-399
PISKIETVPVTLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKISKIGPENPYNTPV
FVIKRKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLNKHKSVTVLDVGDAYYSIPL
YESFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPSIFQSSMTKILEPFKSKNPEIVI
CQYMDDLYVASDLELEQHRTKIEELRAHLLSWGLTTPDKKYQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVVPLTKEAE
LELAENREILKDPVQGAYYDPSKDLTAEIQKQGDGQWTYQIYQEPFKNLKTGKYAKKRSA
HSNDVRQLVDVVQKVSTESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006