Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3315 | 3315-30911 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I54V, V82S, L90M | L10F, L33F | E34Q, M36L, N37D, R41K, D60E, I62V, L63P, A71I, I72L, I93L |
| >3315-30911| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVFQELDLPGKWKPKMIMGIGGFVKVRQYE QVPIEICGHKILGTVLVGPTPSNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | T27S, T39A, E44D, V60I, V118I, K122E, I135V, T139A, D177E, I178M, T200TA, E203K, Q207E, H208Y, R211K, K223E, S251T, A272P, V276T, K277R, Q278E, L283I, T286TA, I293V, E298G, E312AT, G333E, Q334N, G335C, M357T, A371V, K390R, E399D, A400S |
| >3315-30911| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICAELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNEAPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTPDNKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDTWTVNDIQKLVGKLNWASQIYPGIKTRELCKLIRGAKALTEVVPLTEGAE LELAENREILKTPVHGVYYDPSKDLIAEIQKQENCQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWDS |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |