<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3315 3315-30911 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48M, I54V, V82S, L90M L10F, L33F E34Q, M36L, N37D, R41K, D60E, I62V, L63P, A71I, I72L, I93L  
>3315-30911| codons 1-99
PQITLWQRPFVTIKIGGQLKEALLDTGADDTVFQELDLPGKWKPKMIMGIGGFVKVRQYE
QVPIEICGHKILGTVLVGPTPSNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N     T27S, T39A, E44D, V60I, V118I, K122E, I135V, T139A, D177E, I178M, T200TA, E203K, Q207E, H208Y, R211K, K223E, S251T, A272P, V276T, K277R, Q278E, L283I, T286TA, I293V, E298G, E312AT, G333E, Q334N, G335C, M357T, A371V, K390R, E399D, A400S  
>3315-30911| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSVNNEAPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
YQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTPDNKHQEEPPFLWMGYELHPDKWT
VQPIVLPEKDTWTVNDIQKLVGKLNWASQIYPGIKTRELCKLIRGAKALTEVVPLTEGAE
LELAENREILKTPVHGVYYDPSKDLIAEIQKQENCQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWDS

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006