Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3313 | 3313-30929 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, K70G, L210W, T215Y | K219Q | Y188L | I2V, P4S, V35M, T39TA, E44ED, V106VI, I135T, K173E, I178IM, V179I, G196E, E203K, Q207E, H208Y, R211K, D218E, A272P, V317A, Q334IV, R356K, M357LS, G359S, E370ED, A371AV, K390R |
| >3313-30929| codons 1-400 PVSSIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDMII YQYMDDLLVGSDLEIEQHRTKIKELREYLWKWGFYTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGVGQWTYQIYQEPFKNLKTGKYAKSRSA HTNDVKQLTDVVQKIATESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A, L90M | V11I, L33F, K43T | L10I, I13V, L19T, K20KR, Q61E, I62V, L63P, A71L, I72IT, V77I, I93L |
| >3313-30929| codons 1-99 PQITLWQRPIITVKIGGQTREALLDTGADDTVFEEMNLPGRWTPKMIVGIGGFTKVRQYD EVPIEICGHKLTGTVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |