<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3310 3310-30909 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A L24I L10I, I15V, K20R, E35D, M36I, N37D, K55KR, I62V, L63C, I64V, T74S  
>3310-30909| codons 1-99
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEDIDLPGRWKPKLIGGIGGFVRVRQYD
QVCVEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T215F K219Q K101P, K103N   T39A, D123E, I167IV, D177E, V179I, G196E, I202IV, E203D, R211K, V245M, A272P, I293V, E297A, I326V, I329V, Q334E, G335S, R356K, A360T, L368X, A371V, V381I, E399D  
>3310-30909| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLPKNKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFRKQNPEIII
YQYMDDLYVGSDLEIEQHRTKVDELRQHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLVAEVQKQGESQWTYQIYQEPFKNLKTGKYAKMRGT
HTNDVKQVTEVVQKIATESIIIWGKTPKFKLPIQKETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006