Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3310 | 3310-30909 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I | L10I, I15V, K20R, E35D, M36I, N37D, K55KR, I62V, L63C, I64V, T74S |
| >3310-30909| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEDIDLPGRWKPKLIGGIGGFVRVRQYD QVCVEICGHKAIGSVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T215F | K219Q | K101P, K103N | T39A, D123E, I167IV, D177E, V179I, G196E, I202IV, E203D, R211K, V245M, A272P, I293V, E297A, I326V, I329V, Q334E, G335S, R356K, A360T, L368X, A371V, V381I, E399D |
| >3310-30909| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLPKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFRKQNPEIII YQYMDDLYVGSDLEIEQHRTKVDELRQHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLVAEVQKQGESQWTYQIYQEPFKNLKTGKYAKMRGT HTNDVKQVTEVVQKIATESIIIWGKTPKFKLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |