Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3309 | 3309-30902 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | G190A | K101H | P4S, K20R, E28EK, V35I, K43E, E44A, A98S, V118I, K122E, I142V, Q174R, T200A, E203D, Q207E, H208Y, R211K, K223Q, L228H, V245E, S251H, A272P, K277R, T286A, V292I, I293V, E297R, I329IV, G333E, G359S, S379C, K390R | W212Q |
| >3309-30902| codons 1-400 PISSIETVPVKLKPGMDGPRVKQWPLTKEKIKALIEICTELEEAGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLHKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI YQYVDDLYVASDLEIGQHRAKIDELREYLWKQGFYTPDKKHQQEPPFHWMGYELHPDKWT VQPIELPEKDHWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEIVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQEQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47V, G48MV, I54V, V82C, L90M | L33F, K43T, G73AT, L89V | L10IV, E35D, M36I, Q61QE, I62V, L63P, A71T, I72IT, I93L |
| >3309-30902| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTVFEDINLPGRWTPKMVVGIGGFVKVRQYD EVPIEICGHKTTTTVLVGPTPCNIIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |