Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3307 | 3307-30826 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_CG, K70E, L74V, L210W, T215Y | D67S | L100I, K103N | K20R, K64R, K122E, V179VAIT, G196E, E203D, R211K, H221Y, L228H, A272P, T286P, P294T, E297R, Q334E, V381I, I382V |
| >3307-30826| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIRKKSSSEWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDITI YQYMDDLYVGSDLEIEQHRTKIDELRQHLWKWGFYTPDKKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGPKALTEVITLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIIVWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | V11I, L33I, K43T, G73S | L10I, T12P, L19P, K20M, A22V, E35D, M36I, I62V, L63P, A71V, I72L, I85V |
| >3307-30826| codons 1-99 PQITLWQRPIIPIKIGGQPMEVLLDTGADDTVIEDINLPGRWTPKMIGGIGGFVKVRQYD QVPIEICGHKVLSTVLVGPTPANIVGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |