Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3305 | 3305-30801 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, V75M, M184V, T215Y | D67E | G190S | E44D, S68G, K101Q, K122E, S162C, V189I, R211K, A272P, K277R, A288S, P294T, E297K, R307RK, K311KR, I326V, G333E, Q334H, R356K, G359S, V365I |
| >3305-30801| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKEGTKWRKVMDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYISSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVITLTKEAE LELAENKEILREPVHGVYYDPSKDLVAEIQKQEHGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48GA, I54V, V82S | L10V, I15V, K20R, E35D, M36I, N37D, R57K, L63P, I64V, I85V |
| >3305-30801| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDIDLPGRWKPKMIAGIGGFVKVKQYD QIPVEICGHKAIGTVLVGPTPSNIVGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |