<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3305 3305-30801 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48GA, I54V, V82S   L10V, I15V, K20R, E35D, M36I, N37D, R57K, L63P, I64V, I85V  
>3305-30801| codons 1-99
PQITLWQRPVVTIKVGGQLREALLDTGADDTVLEDIDLPGRWKPKMIAGIGGFVKVKQYD
QIPVEICGHKAIGTVLVGPTPSNIVGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, V75M, M184V, T215Y D67E G190S   E44D, S68G, K101Q, K122E, S162C, V189I, R211K, A272P, K277R, A288S, P294T, E297K, R307RK, K311KR, I326V, G333E, Q334H, R356K, G359S, V365I  
>3305-30801| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV
FAIKKKEGTKWRKVMDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYVDDLYISSDLEIGQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVITLTKEAE
LELAENKEILREPVHGVYYDPSKDLVAEIQKQEHGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006