<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3299 3299-30818 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74I, V75T, M184V, L210W T215V, K219Q K103N, Y181C, G190A V108VI V21VA, V35M, T39A, K122E, D123E, I142IV, S162D, T200TA, I202V, R211K, D218E, L228H, A272P, K277R, I293V, E297R, G359S, E370D, A371V, I375V, A376S, T377L, K390R, K395R, E399D  
>3299-30818| codons 1-399
PISPIETVPVKLKPGMDGPKAKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV
FAIKKKNSDKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL
DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI
CQYVDDLYVASDLEIGQHRAKVEELRQHLWKWGFVTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTDVVQKVSLESIVIWGKTPKFRLPIQRETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54M, L76V, I84V, L90M L33F, G73C L10I, I13V, G16A, L19I, E34Q, I62V, L63P, H69HY, A71V, I72L, V77I  
>3299-30818| codons 1-99
PQITLWQRPIVTVKIAGQIKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFMKVRQYD
QVPIEICGYKVLCTVVIGPTPVNVIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006