Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3299 | 3299-30818 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, I84V, L90M | L33F, G73C | L10I, I13V, G16A, L19I, E34Q, I62V, L63P, H69HY, A71V, I72L, V77I |
| >3299-30818| codons 1-99 PQITLWQRPIVTVKIAGQIKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFMKVRQYD QVPIEICGYKVLCTVVIGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, V75T, M184V, L210W | T215V, K219Q | K103N, Y181C, G190A | V108VI | V21VA, V35M, T39A, K122E, D123E, I142IV, S162D, T200TA, I202V, R211K, D218E, L228H, A272P, K277R, I293V, E297R, G359S, E370D, A371V, I375V, A376S, T377L, K390R, K395R, E399D |
| >3299-30818| codons 1-399 PISPIETVPVKLKPGMDGPKAKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV FAIKKKNSDKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRAKVEELRQHLWKWGFVTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTDVVQKVSLESIVIWGKTPKFRLPIQRETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |