<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3297 3297-30930 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M G73S L10I, I15V, Q18H, K20I, E35D, M36I, N37D, K55R, R57RK, I62V, L63P, C67F, H69K, A71V, I85V, Q92E, I93M, C95V  
>3297-30930| codons 1-99
PQITLWQRPIVTIKVGGHLIEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVRVKQYD
QVPIEIFGKKVISTVLVGPTPVNVVGRNLMTEMGVTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, L210LRW, T215Y K219Q K103N   K20R, V35L, K43KN, E44D, V60I, K64R, K122E, Q174K, N175Y, D177N, I195L, G196E, T200AE, H208HY, R211A, D218E, L228H, V245T, R284K, A288T, I293V, E297K, D324E, I329L, M357T, G359S  
>3297-30930| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTELENDGKISKIGPENPYNTPI
FAIRKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKYPNIVI
YQYVDDLYVGSDLELEQHREKIEELRQYLWAWGFYTPEQKHQKEPPFHWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKTLTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARTRSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006