Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3296 | 3296-40226 | France | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 30 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, Y115YF, Q151M, M184MV | A62V, V75I, F77L, F116Y, T215TI, K219Q | Y181C, G190A | A98G, V108VI | V35I, T39A, K43Q, T69N, K101Q, D123E, T139TA, S162C, R172RK, D177E, T200TAIV, E203D, D218E, L228HQR, A272P, K281R, I293V, E297Q, G359S, A360T, A371T, T386I | V179ILPT |
| >3296-40226| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEQEGKISKIGPENPYNTPV FVIKKKNSNRWRKLIDLRELNKRTQDFWEVQLGIPHPGGLQKKKSVTILDVGDAFYSVPL DKEFRKYTAFTIPSINNEAPGIRYQYNVLPMGWKGSPAIFQCSMTKILEPFKKQNPEITI CQYVDDLYVASDLEIGQHRVKIDELRQHLLRWGFITPEQKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTQEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRST HTNDVKQLTETVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V, L90M | K43T, G73S, L89V | L10V, T12P, I15V, L19P, K20M, E34Q, M36A, K55R, R57K, D60E, I62V, L63P, H69K, A71I, I93M, C95L |
| >3296-40226| codons 1-99 PQITLWQRPVVPIKVGGQPMEALLDTGADDTVLQEANLPGRWTPKIIGGIGGFVRVKQYE QVPIEICGKKIISTVLVGPTPANVIGRNVMTQMGLTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |