Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3296 | 3296-30728 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, Q151M | A62V, V75I, F77L, F116Y, T215TI, K219Q | Y181C, G190GA | A98G, V108VI | P4PT, I5IV, V35VI, T39A, K43Q, T69N, K101Q, D123E, T139TA, S162CY, R172RK, D177E, V179X, V189VI, T200TI, E203ED, D218E, L228LHQ, A272P, K281R, I293V, E297Q, V317VA, G359S, A360T, A371T, T386I |
| >3296-30728| codons 1-399 PISTVETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAEMEQEGKISKIGPENPYNTPV FVIKKKNSNRWRKLIDLRELNKRTQDFWEVQLGIPHPGGLQKKKSVTILDVGDAYYSVPL DKEFRKYTAFTIPSINNEAPGIRYQYNVLPMGWKGSPAIFQYSMTKILEPFKKQNPEIXI CQYMDDLYIASDLEIGQHRIKIDELRQHLLRWGFITPEQKHQKEPPFQWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTQEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRST HTNDVKQLTETVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | K43T, G73S | L10V, T12K, I15V, L19P, K20M, E34EQ, M36LV, L38W, K55R, R57K, I62V, L63P, H69K, A71L, I93M, C95L |
| >3296-30728| codons 1-99 PQITLWQRPVVKIKVGGQPMEALLDTGADDTVLQEVNWPGRWTPKIIGGIGGFVRVKQYD QVPIEICGKKLISTVLVGPTPANIIGRNLMTQMGLTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |