<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3294 3294-30729 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, L76V, V82F, L90M L23I, L33F, Q58E L10I, I13V, K14KR, D60DN, Q61QH, L63P, C67DE, A71AV, V77I, L89M, I93L  
>3294-30729| codons 1-99
PQITLWQRPIVTVRIGGQLKEAILDTGADDTVFEEMNLPGRWKPKLIGGIGGFVKVREYN
HIPIEIEGHKVIGTVVIGPTPFNIIGRNMMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70G, V75M, M184V, T215Y K219Q K103S   K20R, T39A, E44D, V60I, A98S, V118I, D123E, I135T, I142V, T200I, L210LS, D218E, L228H, A272AP, T286A, I293V, G333GE, R356K, S379SC, K390R  
>3294-30729| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSTGWRKLMDFRELNKRTQDFWEVQLGIPHPSGLKKSKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRIKIEELRQHLSRWGFYTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYAKMRGA
HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006