Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3294 | 3294-30729 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82F, L90M | L23I, L33F, Q58E | L10I, I13V, K14KR, D60DN, Q61QH, L63P, C67DE, A71AV, V77I, L89M, I93L |
| >3294-30729| codons 1-99 PQITLWQRPIVTVRIGGQLKEAILDTGADDTVFEEMNLPGRWKPKLIGGIGGFVKVREYN HIPIEIEGHKVIGTVVIGPTPFNIIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70G, V75M, M184V, T215Y | K219Q | K103S | K20R, T39A, E44D, V60I, A98S, V118I, D123E, I135T, I142V, T200I, L210LS, D218E, L228H, A272AP, T286A, I293V, G333GE, R356K, S379SC, K390R |
| >3294-30729| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPI FAIKKKNSTGWRKLMDFRELNKRTQDFWEVQLGIPHPSGLKKSKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRIKIEELRQHLSRWGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |