<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3292 3292-30924 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, M184V, L210W, T215Y   K103KN V108I E28G, V35M, E44D, K49R, V60I, R83K, D123E, I135T, I178L, V189I, Q207K, H208Y, R211E, T286A, R356K, R358K, A360T, K366R, E378EQ, E399D, A400AT  
>3292-30924| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTGEKIKALMEICTELEKDGKISRIGPENPYNTPI
FAIKKKNSTKWRKLMDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYVDDLYIGSDLEIGQHRTKIEELRKYLWEWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMKGT
HTNDVRQLTEAVQKIATQSIVIWGKTPKFKLPIQKETWDT

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47A, I84V F53L L10I, I13V, K20M, E34Q, N37D, L63P, I64V, V77I, L89M  
>3292-30924| codons 1-99
PQITLWQRPIVTVKIGGQLMEALLDTGADDTVLQEMDLPGRWKPKIAGGIGGLIKVRQYD
QIPVEICGHKAIGTVLIGPTPVNVIGRNMLTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006