Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3292 | 3292-30924 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47A, I84V | F53L | L10I, I13V, K20M, E34Q, N37D, L63P, I64V, V77I, L89M |
| >3292-30924| codons 1-99 PQITLWQRPIVTVKIGGQLMEALLDTGADDTVLQEMDLPGRWKPKIAGGIGGLIKVRQYD QIPVEICGHKAIGTVLIGPTPVNVIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K103KN | V108I | E28G, V35M, E44D, K49R, V60I, R83K, D123E, I135T, I178L, V189I, Q207K, H208Y, R211E, T286A, R356K, R358K, A360T, K366R, E378EQ, E399D, A400AT |
| >3292-30924| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTGEKIKALMEICTELEKDGKISRIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYVDDLYIGSDLEIGQHRTKIEELRKYLWEWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMKGT HTNDVRQLTEAVQKIATQSIVIWGKTPKFKLPIQKETWDT |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |