Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3291 | 3291-30919 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54A, V82S | L24I | Q7QE, L10I, T12N, I62V, L63P, A71V, I72V, V77I, I93L | E21T |
| >3291-30919| codons 1-99 PQITLWERPIVNIKIGGQLKTALIDTGADDTVLEEMNLPGRWKPKMIVGIGGFAKVRQYD QVPIEICGHKVVGTVLIGPTPSNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | T39A, K43Q, E44D, V60I, V118I, K122E, I135T, I142V, N175NY, G196E, R211K, D218E, V245Q, A272P, I293V, I329V, K350R, R358K, A371V, K390R, K395R, E399D |
| >3291-30919| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEQDGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQYPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPEKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLRTGKYARMKGA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQRETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |