Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3289 | 3289-30709 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, V82T, L90M | L10R, I15V, L19I, K20T, E35D, I62IV, L63P, A71I, I93L |
| >3289-30709| codons 1-99 PQITLWQRPRVTIKVGGQITEALLDTGADDTILEDMNLPGRWKPKIVGGIGGFIKVRQYD QVPIEICGHKIIGTVLVGPTPTNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L74LV, V75M, M184V, L210W, T215Y | K219KDEN | L100LI, K103KN | A98AG | I94IL, K102KR, V118I, D123E, S162D, K166R, T200A, I202V, E203K, Q207E, R211K, H221HY, A272P, L283I, I293V, Q334E, R356K, G359S, A371AV, A376S, T386I, K390R |
| >3289-30709| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVMDFRELNKRTQDFWEVQLGLPHPGGIKRNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKVKELREHLWKWGFYTPDNKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKISTESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |