<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3289 3289-30709 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, V82T, L90M   L10R, I15V, L19I, K20T, E35D, I62IV, L63P, A71I, I93L  
>3289-30709| codons 1-99
PQITLWQRPRVTIKVGGQITEALLDTGADDTILEDMNLPGRWKPKIVGGIGGFIKVRQYD
QVPIEICGHKIIGTVLVGPTPTNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, L74LV, M184V, L210W, T215Y V75M, K219KDEN L100LI, K103KN A98AG I94IL, K102KR, V118I, D123E, S162D, K166R, T200A, I202V, E203K, Q207E, R211K, H221HY, A272P, L283I, I293V, Q334E, R356K, G359S, A371AV, A376S, T386I, K390R  
>3289-30709| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVMDFRELNKRTQDFWEVQLGLPHPGGIKRNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRAKVKELREHLWKWGFYTPDNKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEVVQKISTESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006