<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3286 3286-30707 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82F, L90M L23I, F53L, Q58E L10I, K14R, I15V, I62V, L63P, A71V, I93L  
>3286-30707| codons 1-99
PQITLWQRPIVTIRVGGQLKEAILDTGADDTVLEEMNLPGRWKPKIIGGIGGLVKVREYD
QVPIEICGHKVIGTVVVGPTPFNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, Q151M, M184V F116Y, T215V, K219Q Y181C, G190A V108I T7A, V35T, V60I, V90I, K101Q, D121H, K122E, A158S, I167V, D177E, G196E, Q207E, A272P, K277R, T286A, E297A, I326V, G359S, V365I, A371V, T386I Y232H
>3286-30707| codons 1-400
PISPIEAVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLQKKKSVTILDVGDAYYSVPL
HEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPSIFQSSMTKVLEPFRKQNPEIVI
CQYVDDLYVASDLEIEQHRTKIEELREHLLRWGFVTPDQKHQKEPPFLWMGHELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTAEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDIKQLTEVVQKIATESIVIWGKIPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006