Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3286 | 3286-30707 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82F, L90M | L23I, F53L, Q58E | L10I, K14R, I15V, I62V, L63P, A71V, I93L |
| >3286-30707| codons 1-99 PQITLWQRPIVTIRVGGQLKEAILDTGADDTVLEEMNLPGRWKPKIIGGIGGLVKVREYD QVPIEICGHKVIGTVVVGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Q151M, M184V | F116Y, T215V, K219Q | Y181C, G190A | V108I | T7A, V35T, V60I, V90I, K101Q, D121H, K122E, A158S, I167V, D177E, G196E, Q207E, A272P, K277R, T286A, E297A, I326V, G359S, V365I, A371V, T386I | Y232H |
| >3286-30707| codons 1-400 PISPIEAVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLQKKKSVTILDVGDAYYSVPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPSIFQSSMTKVLEPFRKQNPEIVI CQYVDDLYVASDLEIEQHRTKIEELREHLLRWGFVTPDQKHQKEPPFLWMGHELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDIKQLTEVVQKIATESIVIWGKIPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |