Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3283 | 3283-30916 | France | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, I84V | G73A, L89V | L10I, I13A, K14KR, L19LI, K20I, L33V, M36I, R41K, K55R, R57RK, D60E, L63P, I66F, H69K |
| >3283-30916| codons 1-99 PQITLWQRPIVTARIGGQIIEALLDTGADDTVVEEINLPGKWKPKIIGGIGGFMRVKQYE QIPIEFCGKKAIATVVVGPTPVNVIGRNVLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_VA, M184V | A62AV | E28K, K32E, V35T, E36A, T39K, K43E, S68RT, K122E, D123S, I142V, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, V245Q, T286A, E291D, V292I, I293V, P294T, S322ST, D324DE, I326V, G335D, R356K, M357K, G359S, A371V, I375V, A376S, K390R |
| >3283-30916| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALTAICKELEEEGKISKIGPENPYNTPV FVIKKKDTSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKEPVHGVYYDPTKELVAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA HTNDVKQLTEVVQKVSTESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |