Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3281 | 3281-30916 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K20R, V35I, E44D, V118I, K122E, E138A, K166KQR, H208Y, R211K, A272P, K277R, T286A, A288T, E297K, F346HY, R356K, M357T, R358K, K390R, K395KR |
| >3281-30916| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKTLTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPYKNLKTGKYAKTKGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQRETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, I84V, L90M | L10F, L33LI, G73S, N83ND, L89V | I13V, Q18H, K20I, E34K, M36I, R41RK, I62V, L63P, A71IT |
| >3281-30916| codons 1-99 PQITLWQRPFVTVKIGGHLIEALLDTGADDTVIKEINLPGKWKPKIIGGIGGFMKVRQYD QVPIEICGHKTISTVVVGPTPVDVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |