Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3278 | 3278-30910 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L33F, F53L, G73S | L10I, I13V, G16A, L24F, N37D, Q61H, L63P, I64IM, A71V, I72L, I93L |
| >3278-30910| codons 1-99 PQITLWQRPIVTVKIAGQLKEALFDTGADDTVFEEMDLPGRWKPKIIGGIGGLVKVRQYD HIPMEICGHKVLSTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | L100I, K103N | A98G | P4S, T7P, K20R, V35IM, T39TAEK, K43E, E44A, D121DH, K122KE, D123DE, I135IM, I142IV, S162C, I178L, V179I, G196E, H208Y, R211K, V245T, A272P, I293V, V317A, I329L, G333GE, Q334N, M357T, R358K, K390R, E399D |
| >3278-30910| codons 1-400 PISSIEPVPVKLKPGMDGPRVKQWPLTEEKIKALMEICKELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAYFSVPL HEEFRKYTAFTIPSMNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLII YQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAELQKQENGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |