<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3278 3278-30910 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L33F, F53L, G73S L10I, I13V, G16A, L24F, N37D, Q61H, L63P, I64IM, A71V, I72L, I93L  
>3278-30910| codons 1-99
PQITLWQRPIVTVKIAGQLKEALFDTGADDTVFEEMDLPGRWKPKIIGGIGGLVKVRQYD
HIPMEICGHKVLSTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219N L100I, K103N A98G P4S, T7P, K20R, V35IM, T39TAEK, K43E, E44A, D121DH, K122KE, D123DE, I135IM, I142IV, S162C, I178L, V179I, G196E, H208Y, R211K, V245T, A272P, I293V, V317A, I329L, G333GE, Q334N, M357T, R358K, K390R, E399D  
>3278-30910| codons 1-400
PISSIEPVPVKLKPGMDGPRVKQWPLTEEKIKALMEICKELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAYFSVPL
HEEFRKYTAFTIPSMNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLII
YQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAELQKQENGQWTYQIYQEPFKNLKTGKYARTKGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006