Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3277 | 3277-30731 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, Q58E, G73A | I13M, L19I, K20I, M36MI, K55R, D60E, L63P, I64V, A71T, I72L |
| >3277-30731| codons 1-99 PQITLWQRPFVTMKIGGQIIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVRVREYE QIPVEICGHKTLATVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, K70R, T215F | K219Q, N348I | K103N, Y181C | P4PS, T7TP, T39A, V60VI, V90I, V118I, K122P, I135IV, I142V, A158S, T165I, D177E, I178L, F214L, D218E, L228H, A272P, K277R, T286A, E297A, R358K, A376T |
| >3277-30731| codons 1-398 PISSIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPSIFQSSMIKILEPFRKQNPELVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMKGA HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETW |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |