Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3276 | 3276-30716 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54A, V82A, L90M | L10F, G73S, L89V | Q7QE, I15V, G16E, M36L, R41RK_KR, K55R, R57RK, Q61H, L63T, K70T, A71V, I93L |
| >3276-30716| codons 1-99 PQITLWERPFVTIKVEGQLKEALLDTGADDTVLEELNLPGKWKPKLIGGIGGFARVKQYD HITIEICGHTVISTVLVGPTPANIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L210W, T215Y | K219E | K101E, Y181C | E138K | V35I, T39A, K43E, E44A, R83K, K104KR, V118I, D123E, D177E, T200A, H208Y, D218E, L228R, V245Q, A272P, K275R, I293V, Q334L, K350KR, M357T, V365I, E370Q, A376S, S379C, K390R, I393V, K395R |
| >3276-30716| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEEAGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLEKKRSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNKTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRAKIEELRQYLWRWGFYTPEEKHQKEPPFRWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLRTGKYARTRGA HTNDIKQLTQAVQKISTECIVIWGKTPKFRLPVQRETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |