<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3275 3275-40728 France 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 52

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V82S, I84V, L90M K43KT L10I, I13V, K20KR, E34ED, E35ED, M36I, I62V, L63P, I64V, A71V, I72V  
>3275-40728| codons 1-99
PQITLWQRPIVTVKIGGQLREALLDTGADDTVLDDINLPGRWTPKMIGGIGGFIKVRQYD
QVPVEICGHKVVGTVLVGPTPSNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, K70KR, L74I, T215F D67G, V75T, K219Q L100I, K103N   K20R, A33G, K122E, I135V, I142V, S162Y, D177N, E194K, G196E, I202IV, R211RK, K223KE, L228LR, V245E, A272P, K277R, I293V, E297R, D324E, Q334E, R356K, M357ML, G359S, T369V, K390R  
>3275-40728| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKGLVEICTELEKEGKISKIGPENPYNTPV
FAIKKKGSDRWRKITDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPNIVI
YQYMDDLYVGSDLKIEQHRTKVEELRQHLLKWGFFTPDQKHQEEPPFRWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKLRSA
HTNDVKQLVEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006