<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3275 3275-40223 France 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 29

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V82S, I84V, L90M   L10I, K20R, E35D, M36I, I62V, L63P, I64V, A71V, I72V  
>3275-40223| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD
QVPVEICGHKVVGTVLVGPTPSNVIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L74I, V75T, T215F D67G, K219Q L100I, K103N   K20R, A33G, K122E, I135V, I142V, S162Y, D177N, G196E, R211K, K223E, L228R, V245E, A272P, K277R, I293V, E297R, D324E, Q334E, R356K, G359S, T369V, A376T, K390R  
>3275-40223| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKGLVEICTELEKEGKISKIGPENPYNTPV
FAIKKKGSDKWRKITDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPNIVI
YQYMDDLYVGSDLEIEQHRTKIEELRQHLLKWGFFTPDQKHQEEPPFRWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLVEAVQKITTESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006