Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3275 | 3275-40223 | France | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 29 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82S, I84V, L90M | L10I, K20R, E35D, M36I, I62V, L63P, I64V, A71V, I72V |
| >3275-40223| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QVPVEICGHKVVGTVLVGPTPSNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74I, V75T, T215F | D67G, K219Q | L100I, K103N | K20R, A33G, K122E, I135V, I142V, S162Y, D177N, G196E, R211K, K223E, L228R, V245E, A272P, K277R, I293V, E297R, D324E, Q334E, R356K, G359S, T369V, A376T, K390R |
| >3275-40223| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKGLVEICTELEKEGKISKIGPENPYNTPV FAIKKKGSDKWRKITDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPNIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLKWGFFTPDQKHQEEPPFRWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLVEAVQKITTESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |