Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3275 | 3275-30730 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, K70KR, L74I, V75T, T215F | D67G, K219Q | L100I, K103N | K20R, A33G, K122E, I135V, I142V, S162Y, D177N, G196E, I202V, K223KEQ, L228LR, V245E, A272P, K277R, I293V, E297R, D324E, Q334E, R356K, M357ML, G359S, T369V, K390R |
| >3275-30730| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKGLVEICTELEKEGKISKIGPENPYNTPV FAIKKKGSDRWRKITDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPNIVI YQYMDDLYVGSDLEIEQHRTKVEELRQHLLRWGFFTPDQKHQQEPPFRWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGEGQWTYQIYQEPFKNLKTGKYAKLRSA HTNDVKQLVEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, V82S | L33F | L10I, K20R, M36I, L63P, I64V, A71V, I72V |
| >3275-30730| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVFEEINLPGRWKPKIIGGVGGFIKVRQYD QIPVEICGHKVVGTVLVGPTPSNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |