<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3273 3273-30701 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, V75T, M184MV, L210W, T215Y A62V, K219E Y181C, G190A   V35VI, E44D, K122E, R172RK, V179VI, H208Y, R211RK, D218E, L228H, V245T, A272S, A288S, V317A, I329L, Q334QL, M357S, G359S, K366R, T369A, A376T, T377Q, T386I  
>3273-30701| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV
FVIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIII
CQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPEEKHQKEPPFHWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKSLTEVIPLTEEAE
LELAENREILKEPVHGAYYDPSKDLIAELQKQGLGQWTYQIYQEPFKNLKTGKYARSRSA
HTNDVRQLAEAVQKITQESIVIWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A L23I, Q58E L10I, I15V, K20R, M36I, R41K, G51A, L63P, H69R, A71V, I93L  
>3273-30701| codons 1-99
PQITLWQRPIVTIKVGGQLREAILDTGADDTVLEEINLPGKWKPKIIGGIAGFVKVREYD
QIPIEICGRKVIGTVVVGPTPANIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006