Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3273 | 3273-30701 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184MV, L210W, T215Y | A62V, K219E | Y181C, G190A | V35VI, E44D, K122E, R172RK, V179VI, H208Y, R211RK, D218E, L228H, V245T, A272S, A288S, V317A, I329L, Q334QL, M357S, G359S, K366R, T369A, A376T, T377Q, T386I |
| >3273-30701| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FVIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIII CQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPEEKHQKEPPFHWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKSLTEVIPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAELQKQGLGQWTYQIYQEPFKNLKTGKYARSRSA HTNDVRQLAEAVQKITQESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A | L23I, Q58E | L10I, I15V, K20R, M36I, R41K, G51A, L63P, H69R, A71V, I93L |
| >3273-30701| codons 1-99 PQITLWQRPIVTIKVGGQLREAILDTGADDTVLEEINLPGKWKPKIIGGIAGFVKVREYD QIPIEICGRKVIGTVVVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |