Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-3271 | 3271-30718 | France | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W, T215Y | D67G | Y181C, G190A | V35X, T39TA, K43KN, R83K, V118VI, K122P, D177E, G196E, T200TA, E203K, Q207E, L228H, A272S, K277R, Q278H, T286A, I293V, P294A, E297R, I329L, Q334E, M357I, R358RK, A360AV, A376T, T386A, K390R |
| >3271-30718| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALXEICAELENEGKISKIGPENPYNTPV FAIKKKGSDKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVASDLEIEQHRAKIKELREHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVRHLCKLLRGAKALTEVVALTREAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARIKGV HTNDVKQLTEAVQKITTESIVIWGKAPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L10F, L24I, L33F, G73C | I13IV, R41K, F53W, K55R, D60E, Q61E, I62V, L63P, A71V, I72IT |
| >3271-30718| codons 1-99 PQITLWQRPFVTVKIGGQLKEALIDTGADDTVFEEMNLPGKWKPKIIGGIGGWVRVRQYE EVPIEICGHKVTCTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |