<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-3271 3271-30718 France 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A L10F, L24I, L33F, G73C I13IV, R41K, F53W, K55R, D60E, Q61E, I62V, L63P, A71V, I72IT  
>3271-30718| codons 1-99
PQITLWQRPFVTVKIGGQLKEALIDTGADDTVFEEMNLPGKWKPKIIGGIGGWVRVRQYE
EVPIEICGHKVTCTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L210W, T215Y D67G Y181C, G190A   V35X, T39TA, K43KN, R83K, V118VI, K122P, D177E, G196E, T200TA, E203K, Q207E, L228H, A272S, K277R, Q278H, T286A, I293V, P294A, E297R, I329L, Q334E, M357I, R358RK, A360AV, A376T, T386A, K390R  
>3271-30718| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALXEICAELENEGKISKIGPENPYNTPV
FAIKKKGSDKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
CQYMDDLYVASDLEIEQHRAKIKELREHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVRHLCKLLRGAKALTEVVALTREAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARIKGV
HTNDVKQLTEAVQKITTESIVIWGKAPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006